Evolutionary Conservation and Interacting Preference for Identifying Protein-DNA Interactions

@article{Chang2008EvolutionaryCA,
  title={Evolutionary Conservation and Interacting Preference for Identifying Protein-DNA Interactions},
  author={Yao-Lin Chang and I-Hsin Liu and Cheng-Yan Kao and Jinn-Moon Yang},
  journal={2008 International Multi-symposiums on Computer and Computational Sciences},
  year={2008},
  pages={1-8}
}
Protein-DNA interactions play a central role in many genetic processes of cells. With the growing crystal structures of protein-DNA complexes, the computational approaches are becoming more and more useful for modeling protein-DNA interactions. This paper proposes template-based alignment with a new scoring function which combined the evolutionary conservation and protein-DNA interacting scores of DNA-contact residues. We showed that the combined scoring function is better to model the protein… CONTINUE READING

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