Evolutionary Changes on the Way to Clathrin-Mediated Endocytosis in Animals.

@article{Dergai2016EvolutionaryCO,
  title={Evolutionary Changes on the Way to Clathrin-Mediated Endocytosis in Animals.},
  author={Mykola Dergai and Anton V. Iershov and Olga Novokhatska and Serhii Pankivskyi and Alla V Rynditch},
  journal={Genome biology and evolution},
  year={2016},
  volume={8 3},
  pages={588-606}
}
Endocytic pathways constitute an evolutionarily ancient system that significantly contributed to the eukaryotic cell architecture and to the diversity of cell type-specific functions and signaling cascades, in particular of metazoans. Here we used comparative proteomic studies to analyze the universal internalization route in eukaryotes, clathrin-mediated endocytosis (CME), to address the issues of how this system evolved and what are its specific features. Among 35 proteins crucially required… CONTINUE READING

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