Evolutionary Analysis of the ErbB Receptor and Ligand Families

  title={Evolutionary Analysis of the ErbB Receptor and Ligand Families},
  author={Richard A. Stein and James V. Staros},
  journal={Journal of Molecular Evolution},
We have compared all available deduced protein sequences of the ErbB family of receptors and their ligands. Analysis of the aligned sequences of the receptors indicates that there are some differences in the receptors that are specific to invertebrates. In addition, comparison of the vertebrate ErbB receptors suggest that a gene duplication event generated two ancestral receptors, the ErbB3/ErbB4 precursor and the ErbB1/ErbB2 precursor. Subsequent gene duplications of these precursors generated… CONTINUE READING


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PHYLIP—Phylogeny inference package (version

  • J Felsenstein
  • 1989
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