Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.

  title={Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.},
  author={Hafumi Nishi and Kosuke Hashimoto and T. Madej and A. Panchenko},
  journal={Progress in molecular biology and translational science},
  • Hafumi Nishi, Kosuke Hashimoto, +1 author A. Panchenko
  • Published 2013
  • Biology, Medicine
  • Progress in molecular biology and translational science
  • Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes. The evolutionary and physical mechanisms of oligomer formation are very diverse and are not well understood. Certain homooligomeric states may be conserved within protein subfamilies and between different subfamilies, therefore providing the specificity to particular substrates while minimizing… CONTINUE READING
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