Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.

@article{Cheung2005EvolutionarilyDH,
  title={Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.},
  author={Timothy H. C. Cheung and Ian R Humphreys and Karen G Potter and Paula S. Norris and Heather M Shumway and Bonnie Robin Tran and Ginelle Patterson and Rochelle M Jean-Jacques and Miri Yoon and Patricia G. Spear and Kenneth M Murphy and Nell S. Lurain and Chris A Benedict and Carl F Ware},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 37},
  pages={13218-23}
}
The herpesvirus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member B and T lymphocyte attenuator (BTLA). Competitive binding analysis and mutagenesis reveals a unique BTLA binding site centered on a critical lysine residue in cysteine-rich domain 1 of HVEM. The BTLA… CONTINUE READING
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