Evolutionarily conserved networks of residues mediate allosteric communication in proteins

  title={Evolutionarily conserved networks of residues mediate allosteric communication in proteins},
  author={G{\"u}rol M. S{\"u}el and S. W. Lockless and M. Wall and R. Ranganathan},
  journal={Nature Structural Biology},
  • Gürol M. Süel, S. W. Lockless, +1 author R. Ranganathan
  • Published 2003
  • Biology
  • Nature Structural Biology
  • A fundamental goal in cellular signaling is to understand allosteric communication, the process by which signals originating at one site in a protein propagate reliably to affect distant functional sites. The general principles of protein structure that underlie this process remain unknown. Here, we describe a sequence-based statistical method for quantitatively mapping the global network of amino acid interactions in a protein. Application of this method for three structurally and functionally… CONTINUE READING
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