Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

@article{Litovchick2007EvolutionarilyCM,
  title={Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.},
  author={Larisa Litovchick and Subhashini Sadasivam and Laurence Florens and Xiaopeng Zhu and Selene K Swanson and Soundarapandian Velmurugan and Runsheng Chen and Michael P Washburn and Xiaole Shirley Liu and James A. DeCaprio},
  journal={Molecular cell},
  year={2007},
  volume={26 4},
  pages={539-51}
}
The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood. In D. melanogaster, RB-dependent repression is mediated in part by the multisubunit protein complex Drosophila RBF, E2F, and Myb (dREAM) that contains homologs of the C. elegans synthetic multivulva class B (synMuvB) gene products. Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a p130 complex… CONTINUE READING
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