Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins

@article{Jnsson2006EvolutionarilyCA,
  title={Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins},
  author={Stef{\'a}n Ragnar J{\'o}nsson and Guylaine Hach{\'e} and Mark D Stenglein and Scott C. Fahrenkrug and Valgerdur Andr{\'e}sdŏttir and Reuben S Harris},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={5683 - 5694}
}
The APOBEC3 proteins are unique to mammals. Many inhibit retrovirus infection through a cDNA cytosine deamination mechanism. HIV-1 neutralizes this host defense through Vif, which triggers APOBEC3 ubiquitination and degradation. Here, we report an APOBEC3F-like, double deaminase domain protein from three artiodactyls: cattle, pigs and sheep. Like their human counterparts, APOBEC3F and APOBEC3G, the artiodactyl APOBEC3F proteins are DNA cytosine deaminases that locate predominantly to the… CONTINUE READING
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