Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.

@article{Sinay2017EvolutionarilyCT,
  title={Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.},
  author={Elien Van Sinay and Olivier Mirabeau and Geert G Depuydt and Matthias Boris Van Hiel and Katleen Peymen and Jan Watteyne and Sven Zels and Liliane Schoofs and Isabel Beets},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 20},
  pages={
          E4065-E4074
        }
}
In vertebrates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. However, a functional equivalent in protostomian animals remains unknown, although TRH receptors are conserved in proto- and deuterostomians. Here we identify a TRH-like neuropeptide precursor in Caenorhabditis elegans that belongs to a bilaterian family of TRH precursors. Using CRISPR/Cas9 and… CONTINUE READING
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