Evolution to the rescue: using comparative genomics to understand long non-coding RNAs

@article{Ulitsky2016EvolutionTT,
  title={Evolution to the rescue: using comparative genomics to understand long non-coding RNAs},
  author={Igor Ulitsky},
  journal={Nature Reviews Genetics},
  year={2016},
  volume={17},
  pages={601-614}
}
  • I. Ulitsky
  • Published 1 October 2016
  • Biology, Medicine
  • Nature Reviews Genetics
Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a multitude of pathways across species, but it remains challenging to understand which of them are important and how their functions are performed. Comparative sequence analysis has been instrumental for studying proteins and small RNAs, but the rapid evolution of lncRNAs poses new challenges that demand new approaches. Here, I review the lessons learned so far from genome-wide mapping and comparisons of lncRNAs… 

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