Evolution rate of hepatitis delta virus RNA isolated in Taiwan

  title={Evolution rate of hepatitis delta virus RNA isolated in Taiwan},
  author={You Chen Chao and Hung‐Shang Tang and Chung‐Te Hsu},
  journal={Journal of Medical Virology},
The complete RNA sequences of hepatitis delta viruses (HDV) isolated at 3 years apart from a chronic delta hepatitis patient in Taiwan were determined. The sequence analysis showed an overall evolution rate of 3.18 × 10−3 substitutions/nucleotide/year. The evolution rates in different parts of HDV RNA varied. The hypervariable region evolved faster (4.55 × 10−3 substi‐tutions/nucleotide/year) than the hepatitis delta antigen (HDAg)‐coding region (2.60 × 10−3 substitutions/nucleotide/year) and… 
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  • P. Dény
  • Biology
    Current topics in microbiology and immunology
  • 2006
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