Evolution of voltage-gated ion channels at the emergence of Metazoa.

@article{Moran2015EvolutionOV,
  title={Evolution of voltage-gated ion channels at the emergence of Metazoa.},
  author={Yehu Moran and Maya Gur Barzilai and Benjamin Joseph Liebeskind and Harold H Zakon},
  journal={The Journal of experimental biology},
  year={2015},
  volume={218 Pt 4},
  pages={515-25}
}
Voltage-gated ion channels are large transmembrane proteins that enable the passage of ions through their pore across the cell membrane. These channels belong to one superfamily and carry pivotal roles such as the propagation of neuronal and muscular action potentials and the promotion of neurotransmitter secretion in synapses. In this review, we describe in detail the current state of knowledge regarding the evolution of these channels with a special emphasis on the metazoan lineage. We… CONTINUE READING
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