Evolution of viral quasispecies in four dominant HlA-A2 restricted T cell epitopes is not a major reason for viral persistence in interferon-treated patients with chronic hepatitis C.

@article{Pingel2002EvolutionOV,
  title={Evolution of viral quasispecies in four dominant HlA-A2 restricted T cell epitopes is not a major reason for viral persistence in interferon-treated patients with chronic hepatitis C.},
  author={Sabine Pingel and S{\'e}bastien Vande Weyer and Peter R. Galle and Hanns F L{\"o}hr},
  journal={Journal of medical virology},
  year={2002},
  volume={66 4},
  pages={
          472-80
        }
}
In most patients, chronic hepatitis C virus (HCV) infection persists despite antiviral treatment with interferon-alpha (IFN-alpha) and ribavirin. The aim of the study was to determine whether HCV could evade cellular immune responses through mutations within T cell epitopes. Viral sequences flanking four major CTL epitopes within the HCV core and envelope regions were analyzed by PCR amplification, cloning and sequencing in seven HLA-A2 positive HCV patients before, during and after antiviral… CONTINUE READING
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