Evolution of the type-1 (Th1)-type-2 (Th2) cytokine paradigm.

  • Daniel R. Lucey
  • Published 1999 in Infectious disease clinics of North America

Abstract

During the past 12 years, since the discovery of murine Th1 and Th2 clones, increasing numbers of cells that make type-1 and type-2 cytokines have been recognized, and a growing number of these cytokines have been described. Emphasis has shifted from the CD4+ T cell, as the source of Th1-Th2 cytokines, to the functional effect of the type-1 and type-2… (More)

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