Evolution of the transforming growth factor-beta superfamily.

  title={Evolution of the transforming growth factor-beta superfamily.},
  author={David W. Burt and A. S. Law},
  journal={Progress in growth factor research},
  volume={5 1},
Transforming growth factor beta 1 (TGF-beta 1) is the prototype of an increasingly complex superfamily of growth and differentiation factors. To date, a total of 74 TGF-beta-like sequences have been published, probably representing 23 distinct genes. These sequences were obtained from mammalian, avian, amphibian and insect species, thus emphasising the ancient nature of the TGF-beta superfamily peptides. This article summarises current hypotheses concerning the evolutionary history of this… CONTINUE READING


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