Evolution of the spectrin repeat.

  title={Evolution of the spectrin repeat.},
  author={Jaime Pascual and Jose Castresana and Matti Saraste},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={19 9},
We now know that the evolution of multidomain proteins has frequently involved genetic duplication events. These, however, are sometimes difficult to trace because of low sequence similarity between duplicated segments. Spectrin, the major component of the membrane skeleton that provides elasticity to the cell, contains tandemly repeated sequences of 106 amino acid residues. The same repeats are also present in alpha-actinin, dystrophin and utrophin. Sequence alignments and phylogenetic trees… CONTINUE READING

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