Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation.

Abstract

v-rel is a viral oncogene that evolved from turkey c-rel, an NF-kappa B-related transcription factor. Numerous structural alterations record the evolutionary selection of v-rel and distinguish it from c-rel. To evaluate the biological significance of these alterations, we constructed a set of five c/v-rel hybrids in which three mutation clusters (c-Rel… (More)

Topics

Cite this paper

@article{Nehyba1994EvolutionOT, title={Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation.}, author={J Nehyba and Radmila Hrdli{\vc}kov{\'a} and E H Humphries}, journal={Journal of virology}, year={1994}, volume={68 4}, pages={2039-50} }