Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation.

@article{Nehyba1994EvolutionOT,
  title={Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation.},
  author={Jiř{\'i} Nehyba and Radmila Hrdli{\vc}kov{\'a} and E H Humphries},
  journal={Journal of virology},
  year={1994},
  volume={68 4},
  pages={2039-50}
}
v-rel is a viral oncogene that evolved from turkey c-rel, an NF-kappa B-related transcription factor. Numerous structural alterations record the evolutionary selection of v-rel and distinguish it from c-rel. To evaluate the biological significance of these alterations, we constructed a set of five c/v-rel hybrids in which three mutation clusters (c-Rel amino acids 1 to 97,222 to 302, and 328 to 598) were differentially distributed. These constructs, in addition to parental v-rel and c-rel and… CONTINUE READING

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