Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor.

@article{Laudet1997EvolutionOT,
  title={Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor.},
  author={Vincent Laudet},
  journal={Journal of molecular endocrinology},
  year={1997},
  volume={19 3},
  pages={
          207-26
        }
}
  • V. Laudet
  • Published 1997
  • Biology, Medicine
  • Journal of molecular endocrinology
Key MethodFrom a database containing the published nuclear hormone receptor (NR) sequences I constructed an alignment of the C, D and E domains of these molecules. Using this alignment, I have performed tree reconstruction using both distance matrix and parsimony analysis. The robustness of each branch was estimated using bootstrap resampling methods. The trees constructed by these two methods gave congruent topologies. From these analyses I defined six NR subfamilies: (i) a large one clustering thyroid…Expand
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