Evolution of the neuron-specific alternative splicing product of the c-src proto-oncogene.

  title={Evolution of the neuron-specific alternative splicing product of the c-src proto-oncogene.},
  author={Friedrich Raulf and S. R. M. Robertson and Manfred Schartl},
  journal={Journal of neuroscience research},
  volume={24 1},
The observation of a slower migrating form of pp60c-src in neural tissue of chicken and mouse has recently been shown to be due to an alternative transcript form of the c-src gene (Martinez et al.: Science 237:411-415, 1987; Levy et al.: Mol Cell Biol 7:4142-4145, 1987). An insertion of 18 basepairs between exons 3 and 4, presumed to be due to alternative splicing of a mini-exon, gives rise to six amino acid residues not found in the non-neuronal (termed fibroblastic) form of pp60c-src. We have… CONTINUE READING


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