Evolution of the mammalian G protein α subunit multigene family

@article{Wilkie1992EvolutionOT,
title={Evolution of the mammalian G protein $\alpha$ subunit multigene family},
author={Thomas M. Wilkie and Debra J. Gilbert and Anne S. Olsen and Xiao-Ning Chen and Thomas T. Amatruda and Julie R. Korenberg and Barbara J. Trask and Pieter J. de Jong and Randall R. Reed and Melvin I. Simon and Nancy A. Jenkins and Neal G. Copeland},
journal={Nature Genetics},
year={1992},
volume={1},
pages={85-91}
}
Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein α subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 Gα subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 Gα subunit genes using an interspecific…
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