Evolution of the intracellular changes in neurons caused by trimethyltin.

  title={Evolution of the intracellular changes in neurons caused by trimethyltin.},
  author={Allen W. Brown and John B. Cavanagh and Richard D. Verschoyle and M. F. Gysbers and Huw B. Jones and W. Aldridge},
  journal={Neuropathology and applied neurobiology},
  volume={10 4},
Rats have been given a single dose of trimethyltin (10 mg/kg) and the intracellular events have been followed particularly in hippocampus, cerebral cortex, cerebellum and spinal ganglion cells. The earliest change visible occurs 12 h after this dose and is found to be dense membrane-bound bodies, probably derived from branching tubulo-vesicular smooth endoplasmic reticulum formations. These occur in close connection with rought endoplasmic reticulum and polyribosomes and appear also to have… CONTINUE READING
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