Evolution of the innate immune system: the worm perspective

@article{Schulenburg2004EvolutionOT,
  title={Evolution of the innate immune system: the worm perspective},
  author={Hinrich Schulenburg and C. L{\'e}opold Kurz and Jonathan J. Ewbank},
  journal={Immunological Reviews},
  year={2004},
  volume={198}
}
Summary:  Simple model organisms that are amenable to comprehensive experimental analysis can be used to elucidate the molecular genetic architecture of complex traits. They can thereby enhance our understanding of these traits in other organisms, including humans. Here, we describe the use of the nematode Caenorhabditis elegans as a tractable model system to study innate immunity. We detail our current understanding of the worm's immune system, which seems to be characterized by four main… 

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References

SHOWING 1-10 OF 177 REFERENCES

Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host–pathogen model

TLDR
The soil‐borne nematode, Caenorhabditis elegans, is emerging as a versatile model in which to study host–pathogen interactions and experiments aimed at identifying host innate immunity genes have implicated pathways that have been suggested to play a role in plants and animals, such as the p38 MAP kinase pathway.

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

TLDR
To identify new Drosophila genes involved in the immune response, monitoring the gene expression profile of adult flies in response to microbial infection by using high-density oligonucleotide microarrays encompassing nearly the full Drosophile genome found a large number of genes with unknown function that may be involved in control and execution of theimmune response.

A genome-wide analysis of immune responses in Drosophila

TLDR
A genome-wide analysis of immune-challenged Drosophila infected with Gram-positive or Gram-negative bacteria, or with fungi found a significant number of previously unseen immune-induced genes, some of which fit into the current conceptual framework of host defense and others offer new avenues for research.

Evolution of complement as an effector system in innate and adaptive immunity

TLDR
The group is interested in understanding the role of complement in innate and adaptive immune responses in an evolutionary relevant species: the teleost fish, which offers a unique feature, which is the structural and functional diversity of its main effector protein, C3, the third component of the complement system.

Signals from the reproductive system regulate the lifespan of C. elegans

TLDR
The C. elegans insulin/IGF-1 system integrates multiple signals to define the animal's rate of ageing, and this study demonstrates an inherent relationship between the reproductive state of this animal and its lifespan, and may have implications for the co-evolution of reproductive capability and longevity.
...