Evolution of the innate immune system: the worm perspective

  title={Evolution of the innate immune system: the worm perspective},
  author={Hinrich Schulenburg and C. L{\'e}opold Kurz and Jonathan J. Ewbank},
  journal={Immunological Reviews},
Summary:  Simple model organisms that are amenable to comprehensive experimental analysis can be used to elucidate the molecular genetic architecture of complex traits. They can thereby enhance our understanding of these traits in other organisms, including humans. Here, we describe the use of the nematode Caenorhabditis elegans as a tractable model system to study innate immunity. We detail our current understanding of the worm's immune system, which seems to be characterized by four main… 

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