Evolution of the human sarcomeric-actin genes: Evidence for units of selection within the 3′ untranslated regions of the mRNAs

@article{Gunning1984EvolutionOT,
  title={Evolution of the human sarcomeric-actin genes: Evidence for units of selection within the 3′ untranslated regions of the mRNAs},
  author={P. Gunning and Timothy Mohun and Sun-Yu Ng and Phyllis Ponte and L. Kedes},
  journal={Journal of Molecular Evolution},
  year={1984},
  volume={20},
  pages={202-214}
}
The complete 3′ untranslated region (3′UTR) sequence of the human skeletal-actin gene has been compared with the corresponding regions of the rat and chicken skeletal-actin genes. This comparison reveals that the skeletal-actin 3′UTR is composed of conserved and nonconserved segments. By using genomic Southern transfer blots and thermal stability (Tm) measurements, we found that the cardiac-actin gene 3′UTR also consists of conserved and nonconserved segments. Comparison of human andXenopus… CONTINUE READING

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