Evolution of the hepcidin gene in primates

  title={Evolution of the hepcidin gene in primates},
  author={Ludovica Segat and Alessandra Pontillo and Michele Milanese and Alessandro Tossi and Sergio Crovella},
  journal={BMC Genomics},
  pages={120 - 120}
Hepcidin/LEAP-1 is an iron regulatory hormone originally identified as an antimicrobial peptide. As part of a systematic analysis of the evolution of host defense peptides in primates, we have sequenced the orthologous gene from 14 species of non-human primates. The sequence of the mature peptide is highly conserved amongst all the analyzed species, being identical to the human one in great apes and gibbons, with a single residue conservative variation in Old-World monkeys and with few… CONTINUE READING

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