Evolution of the hepatitis E virus polyproline region: order from disorder.


The hepatitis E virus (HEV) polyproline region (PPR) is an intrinsically unstructured region (IDR). This relaxed structure allows IDRs, which are implicated in the regulation of transcription and translation, to bind multiple ligands. Originally the nucleotide variability seen in the HEV PPR was assumed to be due to high rates of insertion and deletion… (More)
DOI: 10.1128/JVI.01374-12


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