Evolution of the fish heart by sub/neofunctionalization of an elastin gene

  title={Evolution of the fish heart by sub/neofunctionalization of an elastin gene},
  author={Yuuta Moriyama and Fumihiro Ito and Hiroyuki Takeda and Tohru Yano and Masataka Okabe and Shigehiro Kuraku and Fred W Keeley and Kazuko Koshiba-Takeuchi},
  journal={Nature Communications},
The evolution of phenotypic traits is a key process in diversification of life. However, the mechanisms underlying the emergence of such evolutionary novelties are largely unknown. Here we address the origin of bulbus arteriosus (BA), an organ of evolutionary novelty seen in the teleost heart outflow tract (OFT), which sophisticates their circulatory system. The BA is a unique organ that is composed of smooth muscle while the OFTs in other vertebrates are composed of cardiac muscle. Here we… 
The Evolutionary Origin of Elastin: Is Fibrillin the Lost Ancestor?
Considering the remarkable similarities between the hydrophobic domains of the first recognizable elastin gene from the elasmobranch Callorhinchus milii with certain fibrillin regions from related fish species, the possibility that fibrillins might have provided protein domains to an ancestralElastin that thereafter underwent significant evolutionary changes to give the elastIn forms found today.
Transcriptome profile of the zebrafish atrioventricular canal reveals molecular signatures of pacemaker and valve mesenchyme
It is discovered that the zebrafish AVC possesses similar features to the mammalian AV node, including slow conduction, inherent pacemaking activity, and the expression of conserved developmental genes.
Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region
It is shown that abolishing the pacemaker-containing sinoatrial ring through Isl1 loss of function resulted in spontaneous activation in the AVC region, suggesting that it possesses inherent automaticity although insufficient to replace the SAR.
The anatomical components of the cardiac outflow tract of chondrichthyans and actinopterygians
It is suggested herein that the primitive anatomical heart of the jawed vertebrates consisted of a sinus venosus containing the pacemaker tissue, an atrium possessing trabeculated myocardium, and a non‐myocardial bulbus arteriosus that connected the conus with the ventral aorta.
Cardiac septation in heart development and evolution
This review summary summarizes how vertebrates change the structures and functions of their circulatory systems according to environmental changes.
Functional Heterogeneity within the Developing Zebrafish Epicardium
This work elucidates the mutual spatiotemporal relationships between different epicardial subpopulations and assigns unique function to each during cardiac development, and brings us closer to repairing cellular relationships that are disrupted during cardiovascular disease.
Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications
The mechanism of trabeculation of the mixed ventricular myocardium in chondrichthyans is the one that best reproduces how this developmental process has been established from the beginning of the gnathostome radiation.


Differential expression of two tropoelastin genes in zebrafish.
The outflow tract of the heart in fishes: anatomy, genes and evolution.
The authors present the current understanding of both phylogeny and ontogeny of the cardiac outflow tract in fishes and examine how new molecular studies are informing the phylogenetic relationships and evolutionary trajectories that have been proposed.
Chondrichthyans have a bulbus arteriosus at the arterial pole of the heart: morphological and evolutionary implications
These findings, together with other observations in holocephals and several elasmobranch species, confirm that chondrichthyans possess a bulbus arteriosus interposed between the conus arteriosu and the ventral aorta, and indicate that the primitive heart of gnathostomates consists of five intrapericardial components, sinus venosus, atrium, ventricle, conusarteriosus and bulbus arteries.
Latent TGFβ binding protein 3 identifies a second heart field in zebrafish
A requirement for ltbp3–TGF-β signalling during zebrafish SHF development is uncovered, a process that serves to enlarge the single ventricular chamber in this species.
Regressive evolution in Astyanax cavefish.
Recent advances in Astyanax development and genetics have revealed some of the molecular and cellular mechanisms involved in trait modification, the number and identity of the underlying genes and mutations, the molecular basis of parallel evolution, and the evolutionary forces driving adaptation to the cave environment.
Zebrafish cardiac development requires a conserved secondary heart field
Molecular pathways required for secondary heart field development are conserved in teleosts, as it is demonstrated that the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.
Old gene duplication facilitates origin and diversification of an innovative communication system—twice
It is shown that Scn4aa co-option and rapid sequence evolution were tightly coupled to the two origins of electric organ, providing strong evidence that ScN4aa contributed to parallel innovations underlying the evolutionary diversification of each electric fish group.
Conus arteriosus of the teleost heart: dismissed, but not missed.
  • J. Icardo
  • Medicine
    The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
  • 2006
The conus arteriosus has not been lost in evolution and constitutes a fundamental part of the teleost OFT, and in all the species studied, the conus supports the OFT valves, which should be named conus valves.