Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML

@inproceedings{Kollmar2011EvolutionOT,
  title={Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML},
  author={Martin Kollmar and Dawid Lbik and Stefanie Enge},
  booktitle={BMC Research Notes},
  year={2011}
}
WASP family proteins stimulate the actin-nucleating activity of the ARP2/3 complex. They include members of the well-known WASP and WAVE/Scar proteins, and the recently identified WASH and WHAMM proteins. WASP family proteins contain family specific N-terminal domains followed by proline-rich regions and C-terminal VCA domains that harbour the ARP2/3-activating regions. To reveal the evolution of ARP2/3 activation by WASP family proteins we performed a "holistic" analysis by manually assembling… CONTINUE READING
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