Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions.

@article{Yulee1986EvolutionOT,
  title={Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions.},
  author={Li-yuan Yu-lee and L Richter-Mann and C. H. Couch and Adrian Francis Stewart and Antony G. Mackinlay and Jeffrey M. Rosen},
  journal={Nucleic acids research},
  year={1986},
  volume={14 4},
  pages={
          1883-902
        }
}
The rat alpha- and bovine alpha s1-casein genes have been isolated and their 5' sequences determined. The rat alpha-, beta-, gamma- and bovine alpha s1-casein genes contain similar 5' exon arrangements in which the 5' noncoding, signal peptide and casein kinase phosphorylation sequences are each encoded by separate exons. These findings support the hypothesis that during evolution, the family of casein genes arose by a process involving exon recruitment followed by intragenic and intergenic… CONTINUE READING
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