Evolution of the aflatoxin gene cluster

  title={Evolution of the aflatoxin gene cluster},
  author={Kenneth C. Ehrlich},
  journal={Mycotoxin Research},
WhyAspergillus species produce aflatoxin remains an unsolved question. In this report we suggest that evolution of the aflatoxin biosynthesis gene cluster has been a multistep process. More than 300 million years ago a primordial cluster of genes allowed production of anthraquinones that may have served as insect attractants to facilitate spore dispersal. Later adaptive evolutionary steps introduced genes into the cluster that encoded enzymes associated with fungal virulence. These genes may… CONTINUE READING

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