Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences

@article{Eck1966EvolutionOT,
  title={Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences},
  author={R. Ritsema van Eck and M. O. Dayhoff},
  journal={Science},
  year={1966},
  volume={152},
  pages={363 - 366}
}
The structure of present-day ferredoxin, with its simple, inorganic active site and its functions basic to photon-energy utilization, suggests the incorporation of its prototype into metabolism very early during biochemical evolution, even before complex proteins and the complete modern genetic code existed. The information in the amino acid sequence of ferredoxin enables us to propose a detailed reconstruction of its evolutionary history. Ferredoxin has evolved by doubling a shorter protein… Expand
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    This work was supported by NIH grants Nos