Evolution of the Rab family of small GTP-binding proteins.

  title={Evolution of the Rab family of small GTP-binding proteins.},
  author={Jos{\'e} B. Pereira-Leal and Miguel C. Seabra},
  journal={Journal of molecular biology},
  volume={313 4},
Rab proteins are small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane-associated molecular switches. Here, we have identified the complete Rab families in the Caenorhabditis elegans (29 members), Drosophila melanogaster (29), Homo sapiens (60) and Arabidopsis thaliana (57), and we defined criteria for annotation of this protein family in each organism. We studied sequence conservation… 

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