Evolution of the Primate APOBEC3A Cytidine Deaminase Gene and Identification of Related Coding Regions

Abstract

The APOBEC3 gene cluster encodes six cytidine deaminases (A3A-C, A3DE, A3F-H) with single stranded DNA (ssDNA) substrate specificity. For the moment A3A is the only enzyme that can initiate catabolism of both mitochondrial and nuclear DNA. Human A3A expression is initiated from two different methionine codons M1 or M13, both of which are in adequate but sub… (More)
DOI: 10.1371/journal.pone.0030036

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