Evolution of the Metazoan-Specific Importin α Gene Family

  title={Evolution of the Metazoan-Specific Importin α Gene Family},
  author={D. Adam Mason and Deborah E. Stage and David S. Goldfarb},
  journal={Journal of Molecular Evolution},
Importin αs are import receptors for nuclear localization signal-containing proteins. Most animal importin αs assort into α1, α2, and α3 groups. Studies in Drosophila melanogaster, Caenorhabditis elegans, and mouse suggest that the animal importin α gene family evolved from ancestral plant-like genes to serve paralog-specific roles in gametogenesis. To explore this hypothesis we extended the phylogenetic analysis of the importin α gene family to nonbilateral animals and investigated whether… CONTINUE READING


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