Evolution of the Knowledge of Free Radicals and Other Oxidants

@article{DiMeo2020EvolutionOT,
  title={Evolution of the Knowledge of Free Radicals and Other Oxidants},
  author={Sergio Di Meo and Paola Venditti},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2020},
  volume={2020}
}
Free radicals are chemical species (atoms, molecules, or ions) containing one or more unpaired electrons in their external orbitals and generally display a remarkable reactivity. The evidence of their existence was obtained only at the beginning of the 20th century. Chemists gradually ascertained the involvement of free radicals in organic reactions and, in the middle of the 20th century, their production in biological systems. For several decades, free radicals were thought to cause… 

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References

SHOWING 1-10 OF 418 REFERENCES
Biology of disease: free radicals and tissue injury.
  • B. Freeman, J. Crapo
  • Chemistry, Biology
    Laboratory investigation; a journal of technical methods and pathology
  • 1982
TLDR
This review surveys cellular sources of free radicals and the reactions they can undergo and discusses cellular defenses and adaptive mechanisms.
Proteins are major initial cell targets of hydroxyl free radicals.
  • Juan Du, J. Gebicki
  • Biology, Chemistry
    The international journal of biochemistry & cell biology
  • 2004
Aging: a theory based on free radical and radiation chemistry.
TLDR
It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
The Mechanism of the Homogeneous of Hydrogen and Oxygen
  • Chemistry
  • 2017
According to the generally accepted belief , molecules do not, in most chemical reactions, undergo transformation until they have had imparted to them by some physical agency, such as collision with
Superoxide radicals as precursors of mitochondrial hydrogen peroxide
Mechanisms of Oxidation with Oxygen
  • H. Taube
  • Chemistry
    The Journal of general physiology
  • 1965
TLDR
The electronic structure of oxygen and of two low-lying electronically excited states are described and some of the conditions which must be fulfilled by a reducing system to qualify as storing oxygen in this way are reasonably well understood.
Oxidative stress: the paradox of aerobic life.
  • K. Davies
  • Biology
    Biochemical Society symposium
  • 1995
TLDR
The paradox of aerobic life, or the 'Oxygen Paradox', is that higher eukaryotic aerobic organisms cannot exist without oxygen, yet oxygen is inherently dangerous to their existence and oxidative damage remains an inescapable outcome of aerobic existence.
The distance that a radical formed by ionizing radiation can diffuse in a yeast cell.
TLDR
The calculation of a mean radical diffusion distance in yeast cells from the radiation data on enzymes in cells given in an irradiated medium is concerned with.
Peroxynitrite reductase activity of bacterial peroxiredoxins
TLDR
It is shown that the peroxiredoxin alkylhydroperoxide reductase subunit C from Salmonella typhimurium catalytically detoxifies peroxynitrite to nitrite fast enough to forestall the oxidation of bystander molecules such as DNA.
...
...