Evolution of the Knowledge of Free Radicals and Other Oxidants

  title={Evolution of the Knowledge of Free Radicals and Other Oxidants},
  author={Sergio Di Meo and Paola Venditti},
  journal={Oxidative Medicine and Cellular Longevity},
Free radicals are chemical species (atoms, molecules, or ions) containing one or more unpaired electrons in their external orbitals and generally display a remarkable reactivity. The evidence of their existence was obtained only at the beginning of the 20th century. Chemists gradually ascertained the involvement of free radicals in organic reactions and, in the middle of the 20th century, their production in biological systems. For several decades, free radicals were thought to cause… 

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