Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL

@article{Wu2011EvolutionOT,
  title={Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL},
  author={Baojun Wu and Meng Jin and Yi Zhang and Tiandi Wei and Zengliang Bai},
  journal={Immunogenetics},
  year={2011},
  volume={63},
  pages={835-845}
}
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in… 
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Molecular characterization and evolution analysis of five interleukin-17 receptor genes in large yellow croaker Larimichthys crocea.

Interleukins and Interleukin Receptors Evolutionary History and Origin in Relation to CD4+ T Cell Evolution

Interestingly, eight interleukin families appeared in lampreys, however, only two of them (IL17B, IL17E) evolved under positive selection, which indicates that although lampreys have a unique adaptive immune system that lacks CD4+ T cells, they could be utilizingInterleukins in homologous mode to that of the vertebrates’ immune system.

Characterization and expression analysis of six interleukin-17 receptor genes in grouper (Epinephelus coioides) after Cryptocaryon irritans infection.

Characterization of Lamprey IL-17 Family Members and Their Receptors

A potential role for IL-17 in coordinating the interactions between T-like cells and other cells of the adaptive and innate immune systems in jawless vertebrates is suggested.

Characterization and mucosal responses of interleukin 17 family ligand and receptor genes in channel catfish Ictalurus punctatus.

Evolution of prokaryotic homologues of the eukaryotic SEFIR protein domain.

Cloning and Characterization of Rainbow Trout Interleukin-17A/F2 (IL-17A/F2) and IL-17 Receptor A: Expression during Infection and Bioactivity of Recombinant IL-17A/F2

ABSTRACT Lower vertebrates have been found to possess genes that have similar homology to both interleukin (IL)-17A and IL-17F, which have been termed IL-17A/F. In fish species, several of these…

IL-17 Receptor Family: Structure, Signal Transduction, and Function

This chapter will cover recent update on structure, signaling pathway, and function of IL-17 receptor family.

Monocyte biology conserved across species: Functional insights from cattle

Bulk gene transcription indicates pro-inflammatory and antibacterial roles of cM, while ncM and intM appear to be specialized in regulatory/anti-inflammatory functions and tissue repair, as well as antiviral responses and T-cell immunomodulation.

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

The first evidence that CNVs could influence the pathogenesis of gout is provided, and three novel genes, ABCF1, IL17REL and FCGR3A, which are associated with the risk of g out are identified.

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