Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL

  title={Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL},
  author={Baojun Wu and Meng Jin and Yi Zhang and Tiandi Wei and Zengliang Bai},
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in… 

Interleukins and Interleukin Receptors Evolutionary History and Origin in Relation to CD4+ T Cell Evolution

Interestingly, eight interleukin families appeared in lampreys, however, only two of them (IL17B, IL17E) evolved under positive selection, which indicates that although lampreys have a unique adaptive immune system that lacks CD4+ T cells, they could be utilizingInterleukins in homologous mode to that of the vertebrates’ immune system.

Characterization of Lamprey IL-17 Family Members and Their Receptors

A potential role for IL-17 in coordinating the interactions between T-like cells and other cells of the adaptive and innate immune systems in jawless vertebrates is suggested.

Cloning and Characterization of Rainbow Trout Interleukin-17A/F2 (IL-17A/F2) and IL-17 Receptor A: Expression during Infection and Bioactivity of Recombinant IL-17A/F2

ABSTRACT Lower vertebrates have been found to possess genes that have similar homology to both interleukin (IL)-17A and IL-17F, which have been termed IL-17A/F. In fish species, several of these

IL-17 Receptor Family: Structure, Signal Transduction, and Function

This chapter will cover recent update on structure, signaling pathway, and function of IL-17 receptor family.

Monocyte biology conserved across species: Functional insights from cattle

Bulk gene transcription indicates pro-inflammatory and antibacterial roles of cM, while ncM and intM appear to be specialized in regulatory/anti-inflammatory functions and tissue repair, as well as antiviral responses and T-cell immunomodulation.

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

The first evidence that CNVs could influence the pathogenesis of gout is provided, and three novel genes, ABCF1, IL17REL and FCGR3A, which are associated with the risk of g out are identified.



IL‐17: prototype member of an emerging cytokine family

The large‐scale sequencing of the human and other vertebrate genomes has revealed the presence of additional genes encoding proteins clearly related to IL‐17, thus defining a new family of cytokines, which may have significant roles in inflammatory processes.

Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression

It is demonstrated that the SEFIR domain mediates IL-17RA signaling independently of classic TIR adaptors, such as MyD88 and TRIF, and a previously undescribed“TIR-like loop” (TILL) required for activation of NF-κB, MAPK, and up-regulation of C/EBPβ and C/ EBPδ.

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family.

  • H. LiJ. Chen W. Wood
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
There is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors, a finding consistent with the pleiotropic activities ofIL-17.

SEF/IL-17R (SEFIR) Is Not Enough

A detailed structure-function analysis delineating the C-terminal boundary of the SEFIR-containing region of IL-17RA shows that functionality of this domain requires a large extension to the previously identified SEFIR motif, and shows that this extension is not conserved among IL- 17R family members.

Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex

The biologic activity ofIL-17 is dependent on a complex composed of IL-17RA and IL- 17RC, suggesting a new paradigm for understanding the interactions between the expanded family of IL -17 ligands and their receptors.

IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1*

We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

It is demonstrated for the first time that IL-25-mediated activities require both IL-17RB andIL-17RA and provide another example of an IL- 17 family ligand that utilizes a heteromeric receptor complex.

A Novel Cytokine Receptor-Ligand Pair

Results suggest that IL-17B may be a novel proinflammatory cytokine acting on a restricted set of target cell types and demonstrate the strength of genomic approaches in the unraveling of novel biological pathways.

IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail

It is found that IL-17RC interacts directly with the adaptor/E3 ubiquitin ligase Act1, and that the functional IL- 17RC isoforms containing the extended SEFIR region interact specifically with a phosphorylated isoform of Act1.

IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding

A novel human IL‐17F homolog is reported, and it is shown that it is expressed by activated T cells, can stimulate production of other cytokines such as IL‐6, IL‐8 and granulocyte colony‐stimulating factor, and can regulate cartilage matrix turnover.