Evolution of the Human CNS Cholineric System: Has This Resulted in the Emergence of Psychiatric Disease?

@article{Dean2009EvolutionOT,
  title={Evolution of the Human CNS Cholineric System: Has This Resulted in the Emergence of Psychiatric Disease?},
  author={Brian Dean},
  journal={Australian and New Zealand Journal of Psychiatry},
  year={2009},
  volume={43},
  pages={1016 - 1028}
}
  • B. Dean
  • Published 2009
  • Biology, Medicine
  • Australian and New Zealand Journal of Psychiatry
The aim of the present study was to review the available literature on the evolutionary processes that have led to the development of the human central nervous system (CNS) cholinergic system and to test the hypothesis that such processes may have contributed to the emergence of psychiatric diseases. First, it is clear that the molecular components that have come together to form the cholinergic system in the human CNS initially had functions that were not involved in neurotransmission. Indeed… Expand
Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank
TLDR
A discussion on the significance of changes in levels of serotonin 2A receptors in the cortex of patients with schizophrenia and the relevance of such changes with regards to the pathophysiology of the disorder is discussed. Expand
Heritability of Epigenetic Effects
  • P. Dignam
  • Biology, Medicine
  • The Australian and New Zealand journal of psychiatry
  • 2010
TLDR
Dean's reflection on the evolution of the central nervous system cholinergic system and its possible contribution to schizophrenia is fascinating, but in discussing epigenetics, however, he perhaps underestimates the role epigenetics plays in the development of schizophrenia. Expand

References

SHOWING 1-10 OF 190 REFERENCES
Is Schizophrenia the Price of Human Central Nervous System Complexity?
  • B. Dean
  • Biology, Medicine
  • The Australian and New Zealand journal of psychiatry
  • 2009
TLDR
There is evidence to support the hypothesis that schizophrenia is a disease that develops because of derangements to human-specific CNS functions that have emerged since the authors' species diverged from non-human primates. Expand
Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue
  • B. Dean
  • Medicine
  • Postgraduate medical journal
  • 2002
TLDR
Studies using CNS material obtained postmortem clearly show that the pathology of schizophrenia is complex while the polygenetic nature of the illness may be adding to this complexity. Expand
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
TLDR
The evolution of genes involved in diverse aspects of nervous system biology, including those linked to nervous system development, are examined and it is found that these genes display significantly higher rates of protein evolution in primates than in rodents. Expand
Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?
TLDR
The body of evidence presented suggests that deficits in muscarinic receptors are associated with some forms of schizophrenia and that targeting these receptors could prove to be of therapeutic benefit to patients with the disorder. Expand
Monoamine dysfunction and the pathophysiology and treatment of depression.
  • D. Charney
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 1998
TLDR
The results of a series of investigations confirm the importance of monoamines in the mediation of depressed mood, but also suggest that other brain neural systems may have more of a primary role than previously thought in the pathophysiology of depression. Expand
Muscarinic receptors in schizophrenia.
TLDR
It is argued that it is now imperative that the therapeutic potential of manipulating the activity of muscarinic receptors for the treatment of schizophrenia is fully explored. Expand
Smoking and schizophrenia: abnormal nicotinic receptor expression.
TLDR
The results of these studies suggest the presence of abnormal expression and function of the neuronal nicotinic receptor gene family in schizophrenia. Expand
Mammalian nicotinic acetylcholine receptors: from structure to function.
TLDR
This review provides a comprehensive overview of the advancement of functional and genetic studies in the late 1980s and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body. Expand
Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia
  • D. Mancama, M. Arranz, S. Landau, R. Kerwin
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
TLDR
Results provide evidence in support of altered muscarinic 1 receptor expression in schizophrenia, though further work is needed to corroborate these findings. Expand
The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia.
TLDR
The density of M1 receptors was decreased in the caudate-putamen from the schizophrenic subjects and this data raise the possibility that changes in muscarinic receptors may be involved in the pathology of schizophrenia. Expand
...
1
2
3
4
5
...