Evolution of the Human CNS Cholineric System: Has This Resulted in the Emergence of Psychiatric Disease?

  title={Evolution of the Human CNS Cholineric System: Has This Resulted in the Emergence of Psychiatric Disease?},
  author={Brian Dean},
  journal={Australian and New Zealand Journal of Psychiatry},
  pages={1016 - 1028}
  • B. Dean
  • Published 1 November 2009
  • Psychology, Biology, Medicine
  • Australian and New Zealand Journal of Psychiatry
The aim of the present study was to review the available literature on the evolutionary processes that have led to the development of the human central nervous system (CNS) cholinergic system and to test the hypothesis that such processes may have contributed to the emergence of psychiatric diseases. First, it is clear that the molecular components that have come together to form the cholinergic system in the human CNS initially had functions that were not involved in neurotransmission. Indeed… 

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