Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

  title={Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.},
  author={Francisco Aviles-Jimenez and Darren P. Letley and Gerardo Gonz{\'a}lez-Valencia and Nina R Salama and Javier Torres and John Christopher Atherton},
  journal={Journal of bacteriology},
  volume={186 15},
We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity. 

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Helicobacter pylori genetic diversity within the gastric niche of a single human host.

Proceedings of the National Academy of Sciences of the United States of America • 2001

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