Evolution of the FGF Gene Family

  title={Evolution of the FGF Gene Family},
  author={Silvan Oulion and St{\'e}phanie Bertrand and H{\'e}ctor Escriv{\`a}},
  booktitle={International journal of evolutionary biology},
Fibroblast Growth Factors (FGFs) are small proteins generally secreted, acting through binding to transmembrane tyrosine kinase receptors (FGFRs). Activation of FGFRs triggers several cytoplasmic cascades leading to the modification of cell behavior. FGFs play critical roles in a variety of developmental and physiological processes. Since their discovery in mammals, FGFs have been found in many metazoans and some arthropod viruses. Efforts have been previously made to decipher the evolutionary… CONTINUE READING


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