Evolution of the Chalcone Isomerase Fold from Fatty Acid-Binding to Stereospecific Enzyme

@inproceedings{Ngaki2012EvolutionOT,
  title={Evolution of the Chalcone Isomerase Fold from Fatty Acid-Binding to Stereospecific Enzyme},
  author={Micheline N Ngaki and Gordon V. Louie and Ryan N. Philippe and Gerard Manning and Florence Pojer and M. E. Bowman and Ling Li and Elise Larsen and Eve Syrkin Wurtele and Joseph P Noel},
  booktitle={Nature},
  year={2012}
}
Specialized metabolic enzymes biosynthesize chemicals of ecological importance, often sharing a pedigree with primary metabolic enzymes. However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown. In vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step in the production of plant flavonoids, compounds that contribute to attraction, defence and development. CHI operates near the diffusion limit with stereospecific control. Although… CONTINUE READING
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