Evolution of the Chalcone Isomerase Fold from Fatty Acid-Binding to Stereospecific Enzyme

  title={Evolution of the Chalcone Isomerase Fold from Fatty Acid-Binding to Stereospecific Enzyme},
  author={Micheline N Ngaki and Gordon V. Louie and Ryan N. Philippe and Gerard Manning and Florence Pojer and M. E. Bowman and Ling Li and Elise Larsen and Eve Syrkin Wurtele and Joseph P Noel},
Specialized metabolic enzymes biosynthesize chemicals of ecological importance, often sharing a pedigree with primary metabolic enzymes. However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown. In vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step in the production of plant flavonoids, compounds that contribute to attraction, defence and development. CHI operates near the diffusion limit with stereospecific control. Although… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 57 references

Plantmetabolomics Platform2: fatty acids

  • S. Moon, B. J. Nikolau
  • http://www.plantmetabolomics.org
  • 2009

Structure and function of enzymes involved in the biosynthesis of phenylpropanoids

  • Ferrer, J.-L, M. B. Austin, Stewart, C., J. P. Noel
  • Plant Physiol. Biochem
  • 2008

Similar Papers

Loading similar papers…