Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species

@article{Hu2007EvolutionOT,
  title={Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species},
  author={Shengyong Hu and Haoyi Wang and Alyssa A. Knisely and Shanti Reddy and David Kovacevic and Zhi Liu and Susan M. G. Hoffman},
  journal={Genetica},
  year={2007},
  volume={133},
  pages={215-226}
}
The evolution of gene families can be best understood by studying the modern organization and functions of family members, and by comparing parallel families in different species. In this study, the CYP2ABFGST gene cluster has been characterized in rat and compared to the syntenic clusters in mouse and human, providing an interesting example of gene family evolution. In the rat, 18 loci from six subfamilies have been identified by specifically amplifying and sequencing gene fragments from… CONTINUE READING