Evolution of the COVID-19 vaccine development landscape.

  title={Evolution of the COVID-19 vaccine development landscape.},
  author={Tung Thanh Le and J. Cramer and Robert Chen and S. Mayhew},
  journal={Nature reviews. Drug discovery},
Tras el brote de una enfermedad por un nuevo coronavirus (COVID-19) que se produjo en Wuhan, una ciudad de la provincia de Hubei en China, se ha registrado una rápida propagación a escala comunitaria, regional e internacional, con un aumento exponencial del número de casos y muertes El 30 de enero del 2020, el Director General de la OMS declaró que el brote de COVID-19 era una emergencia de salud pública de importancia internacional de conformidad con el Reglamento Sanitario Internacional (2005… Expand

Figures from this paper

Nuevos mecanismos de colaboración público-privada para el desarrollo y acceso a la vacuna COVID-19: una perspectiva desde la teoría fundamentada
El objetivo de este texto es identificar y caracterizar como ante un hecho global de alto impacto, como puede ser una pandemia, se crean nuevas formas de colaboracion y competencia entre los agentesExpand
COVID-19: Characteristics and Therapeutics
It is speculated that the current pandemic emergency will trigger detailed studies of coronaviruses, their mechanism of infection, development of systematic drug repurposing approaches, and novel drug discoveries for current and future pandemic outbreaks. Expand
Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform
A unified description and meta-analysis of SARS-CoV-2 T cell epitopes compiled from 18 studies of cohorts of convalescent COVID-19 patients is provided, identifying a set of 20 immunoprevalent epitopes that induced T cell responses in multiple cohorts and in a large fraction of tested patients. Expand
A review: Epidemiology, pathogenesis and prospect in developing vaccines for novel Coronavirus (COVID-19)
  • P. Gupta
  • Medicine
  • Indian Journal of Tuberculosis
  • 2020
The ongoing research and advances in designing vaccine and therapeutics against COVID-19 are highlighted, focusing on the epidemiology, transmission, future direction and control the spread of infectious diseases. Expand
Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine
Effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2. Expand
Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges
This study critically reviews the latest scientific advancement in genomics, replication pattern, pathogenesis, and immunopathology of SARS-CoV-2 infection and how these concepts could be used in the development of vaccines. Expand
Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19
This study for the first time provides human serological data for the design of vaccines against COVID-19, and detected epitope-specific antibodies and SARS-CoV-2-neutralising activity in the immunised mice. Expand
Status Report on COVID-19 Vaccines Development
Novel and traditional approaches for COVID-19 vaccine development including inactivated, attenuated, nucleic acid, vector and protein based are summarized. Expand
Overview of the Main Anti-SARS-CoV-2 Vaccines: Mechanism of Action, Efficacy and Safety
Abstract This review takes into consideration the principal vaccines developed against the SARS-CoV-2 in this unprecedented period of Covid-19 pandemic. We evaluated the mechanism of action of eachExpand
New public-private collaboration mechanisms for the development and access to the COVID-19 vaccine: A perspective from grounded theory
The aim of this work is to identify and characterize how in the facing of a global event of high-impact, such as a pandemic, new forms of collaboration and competition among agents (companies, publicExpand