Evolution of the CD4 family: teleost fish possess two divergent forms of CD4 in addition to lymphocyte activation gene-3.

@article{Laing2006EvolutionOT,
  title={Evolution of the CD4 family: teleost fish possess two divergent forms of CD4 in addition to lymphocyte activation gene-3.},
  author={Kerry J. Laing and Jun Zou and M K Purcell and Ruth G Phillips and Christopher J Secombes and John C. Hansen},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={3939-51}
}
The T cell coreceptor CD4 is a transmembrane glycoprotein belonging to the Ig superfamily and is essential for cell-mediated immunity. Two different genes were identified in rainbow trout that resemble mammalian CD4. One (trout CD4) encodes four extracellular Ig domains reminiscent of mammalian CD4, whereas the other (CD4REL) codes for two Ig domains. Structural motifs within the amino acid sequences suggest that the two Ig domains of CD4REL duplicated to generate the four-domain molecule of… CONTINUE READING
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