Evolution of the 4‐anilidopiperidine class of opioid analgesics

@article{Bagley1991EvolutionOT,
  title={Evolution of the 4‐anilidopiperidine class of opioid analgesics},
  author={Jerome R. Bagley and Linas V. Kudzma and Nhora L. Lalinde and John A. Colapret and B. Huang and Bor-Sheng Lin and Thomas P. Jerussi and Mark J. Benvenga and Brian M. Doorley and M. Ossipov and T. Spaulding and H. Kenneth Spencer and Frieda G. Rudo and Richard L. Wynn},
  journal={Medicinal Research Reviews},
  year={1991},
  volume={11}
}
  • Jerome R. Bagley, Linas V. Kudzma, +11 authors Richard L. Wynn
  • Published 1991
  • Biology, Medicine
  • Medicinal Research Reviews
  • The findings reviewed herein have been the results of a five-year project undertaken by Anaquest to discover new therapeutically superior analgesics. The need to provide an analgesic for severe to moderate pain in the perioperative and nonsurgical environment is clear. The current armamentarium includes potent opioids, i.e., morphine and fentanyl, and agonist/antagonists, i.e., nalbuphine. The former provide adequate pain relief, but are not without untoward effects, while the latter have been… CONTINUE READING
    29 Citations
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