Evolution of structure, ontogeny of gene expression, and function of Xenopus laevis transthyretin.

  title={Evolution of structure, ontogeny of gene expression, and function of Xenopus laevis transthyretin.},
  author={Porntip Prapunpoj and Katsuya Yamauchi and Norihito Nishiyama and Samantha J. Richardson and Gideon Schreiber},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={279 6},
Xenopus laevis transthyretin (xTTR) cDNA was cloned and sequenced. The derived amino acid sequence was very similar to those of other vertebrate transthyretins (TTR). TTR gene expression was observed during metamorphosis in X. laevis tadpole liver but not in tadpole brain nor adult liver. Recombinant xTTR was synthesized in Pichia pastoris and identified by amino acid sequence, subunit molecular mass, tetramer formation, and binding to retinol-binding protein. Contrary to mammalian xTTRs, the… CONTINUE READING


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