Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

@article{Dutertre2014EvolutionOS,
  title={Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails},
  author={S. Dutertre and A. Jin and I. Vetter and B. Hamilton and K. Sunagar and Vincent Lavergne and V. Dutertre and B. Fry and A. Antunes and D. J. Venter and P. Alewood and R. Lewis},
  journal={Nature Communications},
  year={2014},
  volume={5}
}
  • S. Dutertre, A. Jin, +9 authors R. Lewis
  • Published 2014
  • Biology, Medicine
  • Nature Communications
  • Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the defence-evoked venom of Conus geographus contains high levels of paralytic toxins that potently block neuromuscular receptors, consistent with its lethal effects on humans. In… CONTINUE READING
    182 Citations

    Figures and Topics from this paper

    The role of defensive ecological interactions in the evolution of conotoxins
    • 28
    Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.
    • 26
    Diet Breadth Mediates the Prey Specificity of Venom Potency in Snakes
    • 9
    • PDF
    Changes in predator exposure, but not in diet, induce phenotypic plasticity in scorpion venom
    • 14
    • PDF

    References

    SHOWING 1-10 OF 46 REFERENCES
    Diet and snake venom evolution
    • 491
    Peptide neurotoxins from fish-hunting cone snails.
    • 674
    Conus venom peptides: correlating chemistry and behavior
    • B. Olivera
    • Chemistry, Medicine
    • Journal of Comparative Physiology A
    • 1999
    • 34
    The venom optimization hypothesis revisited.
    • 115
    Studies of the venoms of some Conidae
    • 57
    The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms.
    • 529
    • PDF
    Developmental modularity and phenotypic novelty within a biphasic life cycle: morphogenesis of a cone snail venom gland
    • L. Page
    • Biology, Medicine
    • Proceedings of the Royal Society B: Biological Sciences
    • 2011
    • 15
    • PDF