Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.

@article{Gladyshev2001EvolutionOS,
  title={Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.},
  author={Vadim N. Gladyshev and Gregory V. Kryukov},
  journal={BioFactors},
  year={2001},
  volume={14 1-4},
  pages={87-92}
}
In the genetic code, UGA serves as either a signal for termination or a codon for selenocysteine (Sec). Sec rarely occurs in protein and is different from other amino acids in that much of the biosynthetic machinery governing its incorporation into protein is unique to this amino acid. Sec-containing proteins have diverse functions and lack a common amino acid motif or consensus sequence. Sec has previously been considered to be a relic of the primordial genetic code that was counter-selected… CONTINUE READING

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