Evolution of secondary structure in the family of 7SL-like RNAs

  title={Evolution of secondary structure in the family of 7SL-like RNAs},
  author={Damian Labuda and Ewa Zitkiewicz},
  journal={Journal of Molecular Evolution},
Primate and rodent genomes are populated with hundreds of thousands copies of Alu and B1 elements dispersed by retroposition, i.e., by genomic reintegration of their reverse transcribed RNAs. These, as well as primate BC200 and rodent 4.5S RNAs, are ancestrally related to the terminal portions of 7SL RNA sequence. The secondary structure of 7SL RNA (an integral component of the signal recognition particle) is conserved from prokaryotes to distant eukaryotic species. Yet only in primates and… CONTINUE READING


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