Evolution of resistance to anti-cancer therapy during general dosing schedules.

@article{Foo2010EvolutionOR,
  title={Evolution of resistance to anti-cancer therapy during general dosing schedules.},
  author={Jasmine Foo and Franziska Michor},
  journal={Journal of theoretical biology},
  year={2010},
  volume={263 2},
  pages={
          179-88
        }
}
Anti-cancer drugs targeted to specific oncogenic pathways have shown promising therapeutic results in the past few years; however, drug resistance remains an important obstacle for these therapies. Resistance to these drugs can emerge due to a variety of reasons including genetic or epigenetic changes which alter the binding site of the drug target, cellular metabolism or export mechanisms. Obtaining a better understanding of the evolution of resistant populations during therapy may enable the… CONTINUE READING

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