Evolution of regional ischemia distal to a proximal coronary stenosis: self-propagation of ischemia.

@article{Guyton1977EvolutionOR,
  title={Evolution of regional ischemia distal to a proximal coronary stenosis: self-propagation of ischemia.},
  author={Robert A. Guyton and James H. McClenathan and Lawrence L. Michaelis},
  journal={The American journal of cardiology},
  year={1977},
  volume={40 3},
  pages={
          381-92
        }
}
The temporal evolution of myocardial ischemia was studied in open chest dogs at constant preload, afterload and heart rate. In one group of animals, a variable circumflex arterial stenosis was used to maintain constant distal circumflex arterial hypotension (40 to 50 mm Hg). During a 3 hour period of stenosis, flow in the subendocardial fourth of the ischemic ventricular wall decreased from 0.22 to 0.09 ml/g per min (P less than 0.02), whereas subepicardial flow was not significantly changed… CONTINUE READING

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